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Widespread Chromatin Accessibility at Repetitive Elements Links Stem Cells with Human Cancer

1 Nov 2016

Abstract excerpt

Chromatin regulation is critical for differentiation and disease. However, features linking the chromatin environment of stem cells with disease remain largely unknown. We explored chromatin accessibility in embryonic and multipotent stem cells and unexpectedly identified widespread chromatin accessibility at repetitive elements. Integrating genomic and biochemical approaches, we demonstrate that these sites of...

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PMID: 27806299
DOI: 10.1016/j.celrep.2016.10.011

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