Article

Cell-of-origin epigenome underlies SS18::SSX-mediated transformation

2024-05-18

Abstract excerpt

<h4>Summary</h4> Synovial sarcoma is an aggressive soft-tissue malignancy that is characterized by a pathognomonic t(X;18)(p11.2;q11.2) translocation, which produces the fusion oncogene named SS18::SSX . Despite recent advancements in our understanding of synovial sarcoma biology, the cell-of-origin remains undefined. A mesenchymal stromal cell (MSC) specific CreERT2 line was employed to express SS18::SSX in fi...

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Identifiers and source

Literature Corpus work: 62327d44-e6a4-593c-beae-434ba810f653
DOI: 10.1101/2024.05.15.594021

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