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Article

HMGB2 holds the key to the senescence-associated secretory phenotype.

The Journal of cell biology - 7 Nov 2016

Guerrero Ana, Gil Jesús

Abstract excerpt

The senescence-associated secretory phenotype (SASP) is a hallmark of senescence with an important physiological impact, but how it is established is unclear. In this issue, Aird et al. (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201608026) describe how chromatin-bound HMGB2 fine tunes SASP expression by avoiding heterochromatin spreading.

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Source

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Identifiers

PMID: 27799373
DOI: 10.1083/jcb.201610044
PMCID: PMC5100298

Genes

HMGB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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