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Article

Propagation of senescent phenotypes by extracellular HMGB1 is dependent on its redox state.

Metabolism: clinical and experimental - 1 Jul 2025

Shin Ji-Won, Jang Dong-Hyun, Kim So Young, Lee Je-Jung, Gil Tae-Hwan, Shim Eunha, Kim Ji Yeon, Kim Hyeon Soo, Conboy Michael J, Conboy Irina M, Wiley Christopher D, Shin Jeon-Soo, Jeon Ok Hee

Abstract excerpt

BACKGROUND & PURPOSE: Cellular senescence spreads systemically through blood circulation, but its mechanisms remain unclear. High mobility group box 1 (HMGB1), a multifunctional senescence-associated secretory phenotype (SASP) factor, exists in various redox states. Here, we investigate the role of redox-sensitive HMGB1 (ReHMGB1) in driving paracrine and systemic senescence. METHODS: We applied the paracrine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40189139
DOI: 10.1016/j.metabol.2025.156259

Genes

HMGB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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