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Article

NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence

3 May 2018

Abstract excerpt

Senescent cells interact with the surrounding microenvironment achieving diverse functional outcomes. We have recently identified that NOTCH1 can drive 'lateral induction' of a unique senescence phenotype in adjacent cells by specifically upregulating the NOTCH ligand JAG1. Here we show that NOTCH signalling can modulate chromatin structure autonomously and non-autonomously. In addition to senescence-associated...

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Share to Genomics and Chromatin Dynamics
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PMID: 29743479
DOI: 10.1038/s41467-018-04283-9

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