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Article

HMGB2 orchestrates the chromatin landscape of senescence-associated secretory phenotype gene loci.

The Journal of cell biology - 7 Nov 2016

Aird Katherine M, Iwasaki Osamu, Kossenkov Andrew V, Tanizawa Hideki, Fatkhutdinov Nail, Bitler Benjamin G, Le Linh, Alicea Gretchen, Yang Ting-Lin, Johnson F Brad, Noma Ken-Ichi, Zhang Rugang

Abstract excerpt

Cellular senescence is a stable cell growth arrest that is characterized by the silencing of proliferation-promoting genes through compaction of chromosomes into senescence-associated heterochromatin foci (SAHF). Paradoxically, senescence is also accompanied by increased transcription of certain genes encoding for secreted factors such as cytokines and chemokines, known as the senescence-associated secretory...

Topics

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Cell Cycle Checkpoints
Cellular Senescence
Chromatin
Gene Expression Regulation
Genetic Loci

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Heterochromatin

Protein Binding

Secretory Pathway

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Identifiers

PMID: 27799366
DOI: 10.1083/jcb.201608026
PMCID: PMC5100296

Genes

HMGB2

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