Article

Histone variant H2A.Z mutant suppresses the senescence-associated secretory phenotype

2026-02-26

Abstract excerpt

<title>Abstract</title> <p>Cellular senescence features a durable cell-cycle arrest and a pro-inflammatory senescence-associated secretory phenotype (SASP) driven in part by chromatin remodeling. The histone variant H2A.Z plays an essential role in regulating gene expression through modulating nucleosome dynamics and is known to regulate the expression of cell cycle genes during the early stages of cellular senes...

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Literature Corpus work: 2e0ec1cd-14d3-5444-b180-e5ecf0a5e971
DOI: 10.21203/rs.3.rs-8818498/v1

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