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Involvement of condensin in cellular senescence through gene regulation and compartmental reorganization

12 Dec 2019

Abstract excerpt

Senescence is induced by various stimuli such as oncogene expression and telomere shortening, referred to as oncogene-induced senescence (OIS) and replicative senescence (RS), respectively, and accompanied by global transcriptional alterations and 3D genome reorganization. Here, we demonstrate that the human condensin II complex participates in senescence via gene regulation and reorganization of euchromatic A...

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PMID: 31831736
DOI: 10.1038/s41467-019-13604-5

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