Article

Genomic instability is an early event driving chromatin reorganization and escape from oncogene-induced senescence

2020-12-20

Abstract excerpt

<h4>SUMMARY</h4> Oncogene-induced senescence (OIS) is an inherent and important tumor suppressor mechanism. However, if not timely removed via immune surveillance, senescent cells will also present a detrimental side. Although this has mostly been attributed to the senescence-associated-secretory-phenotype (SASP) of these cells, we recently proposed that “escape” from the senescent state represents another unfavo...

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Literature Corpus work: 9bce206a-aff8-5f6d-8d33-f1561668c295
DOI: 10.1101/2020.12.20.423639

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