Article
Leukemia-Associated Cohesin Mutants Dominantly Enforce Stem Cell Programs and Impair Human Hematopoietic Progenitor Differentiation.
Cell stem cell - 3 Dec 2015
Mazumdar Claire, Shen Ying, Xavy Seethu, Zhao Feifei, Reinisch Andreas, Li Rui, Corces M Ryan, Flynn Ryan A, Buenrostro Jason D, Chan Steven M, Thomas Daniel, Koenig Julie L, Hong Wan-Jen, Chang Howard Y, Majeti Ravindra
Abstract excerpt
Recurrent mutations in cohesin complex proteins have been identified in pre-leukemic hematopoietic stem cells and during the early development of acute myeloid leukemia and other myeloid malignancies. Although cohesins are involved in chromosome separation and DNA damage repair, cohesin complex functions during hematopoiesis and leukemic development are unclear. Here, we show that mutant cohesin proteins block...
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