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Article

A Nonsense Mutation in Mycobacterium marinum That Is Suppressible by a Novel Mechanism.

Infection and immunity - 1 Feb 2017

Williams Emily A, Mba Medie Felix, Bosserman Rachel E, Johnson Benjamin K, Reyna Cristal, Ferrell Micah J, Champion Matthew M, Abramovitch Robert B, Champion Patricia A

Abstract excerpt

Mycobacterial pathogens use the ESAT-6 system 1 (Esx-1) exporter to promote virulence. Previously, we used gene disruption and complementation to conclude that the MMAR_0039 gene in Mycobacterium marinum is required to promote Esx-1 export. Here we applied molecular genetics, proteomics, and whole-genome sequencing to demonstrate that the MMAR_0039 gene is not required for Esx-1 secretion or virulence. These...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27789543
DOI: 10.1128/IAI.00653-16
PMCID: PMC5278160

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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