Article
A specific secretion system mediates PPE41 transport in pathogenic mycobacteria.
Molecular microbiology - 1 Nov 2006
Abdallah Abdallah M, Verboom Theo, Hannes Fredericke, Safi Mohamad, Strong Michael, Eisenberg David, Musters René J P, Vandenbroucke-Grauls Christina M J E, Appelmelk Ben J, Luirink Joen, Bitter Wilbert
Abstract excerpt
Mycobacterial genomes contain two unique gene families, the so-called PE and PPE gene families, which are highly expanded in the pathogenic members of this genus. Here we report that one of the PPE proteins, i.e. PPE41, is secreted by pathogenic mycobacteria, both in culture and in infected macrophages. As PPE41 lacks a signal sequence a dedicated secretion system must be involved. A single gene was identified in...
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