Article
Essential Role of the ESX-5 Secretion System in Outer Membrane Permeability of Pathogenic Mycobacteria.
PLoS genetics - 1 May 2015
Ates Louis S, Ummels Roy, Commandeur Susanna, van de Weerd Robert, van der Weerd Robert, Sparrius Marion, Weerdenburg Eveline, Alber Marina, Kalscheuer Rainer, Piersma Sander R, Abdallah Abdallah M, Abd El Ghany Moataz, Abdel-Haleem Alyaa M, Pain Arnab, Jiménez Connie R, Bitter Wilbert, Houben Edith N G
Abstract excerpt
Mycobacteria possess different type VII secretion (T7S) systems to secrete proteins across their unusual cell envelope. One of these systems, ESX-5, is only present in slow-growing mycobacteria and responsible for the secretion of multiple substrates. However, the role of ESX-5 substrates in growth and/or virulence is largely unknown. In this study, we show that esx-5 is essential for growth of both Mycobacterium...
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