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Homeostasis of N-α-Terminal Acetylation of EsxA Correlates with Virulence in Mycobacterium marinum

19 Aug 2014

Abstract excerpt

The mycobacterial Esx-1 (ESAT-6 system 1) exporter translocates virulence factors across the cytoplasmic membrane to the cell wall, cell surface, and the bacteriological medium in vitro. The mechanisms underlying substrate targeting to distinct locations are unknown. Several Esx-1 substrates are N-α-terminally acetylated. The role of this rare modification in bacteria is unclear. We sought to identify genes...

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PMID: 25135684
DOI: 10.1128/iai.02153-14

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Homeostasis of N-α-Terminal Acetylation of EsxA Correlates with Virulence in Mycobacterium marinumPMID 25135684Read ↗

An N-acetyltransferase required for EsxA N-terminal protein acetylation and virulence in Mycobacterium marinum.Semantic proximity Read ↗

An N-acetyltransferase required for ESAT-6 N-terminal acetylation and virulence in Mycobacterium marinumSemantic proximity Read ↗

WhiB6 regulation of ESX-1 gene expression is controlled by a negative feedback loop in Mycobacterium marinumSemantic proximity Read ↗

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The EspN transcription factor is an infection-dependent regulator of the ESX-1 system in <i>M. marinum</i>Semantic proximity Read ↗

Functional Analysis of EspM, an ESX-1-Associated Transcription Factor in Mycobacterium marinumSemantic proximity Read ↗

Integrated transcriptomic and proteomic analysis of pathogenic mycobacteria and their esx-1 mutants reveal secretion-dependent regulation of ESX-1 substrates and WhiB6 as a transcriptional regulatorSemantic proximity Read ↗

Proteo-genetic analysis reveals clear hierarchy of ESX-1 secretion in Mycobacterium marinumSemantic proximity Read ↗

The antagonistic transcription factors, EspM and EspN, regulate the ESX-1 secretion system in <i>M. marinum</i>Semantic proximity Read ↗

WhiB6 is required for the secretion-dependent regulation of ESX-1 substrates in pathogenic mycobacteriaSemantic proximity Read ↗

The antagonistic transcription factors, EspM and EspN, regulate the ESX-1 secretion system in M. marinumSemantic proximity Read ↗

EspM Is a Conserved Transcription Factor That Regulates Gene Expression in Response to the ESX-1 SystemSemantic proximity Read ↗

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