Article
The antagonistic transcription factors, EspM and EspN, regulate the ESX-1 secretion system in M. marinum
6 Mar 2024
Abstract excerpt
ABSTRACT Bacterial pathogens use protein secretion systems to transport virulence factors and regulate gene expression. Among pathogenic mycobacteria, including Mycobacterium tuberculosis and Mycobacterium marinum , the ESAT-6 system 1 (ESX-1) secretion is crucial for host interaction. Secretion of protein substrates by the ESX-1 secretion system disrupts phagosomes, allowing mycobacteria cytoplasmic access...
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