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The antagonistic transcription factors, EspM and EspN, regulate the ESX-1 secretion system in M. marinum

6 Mar 2024

Abstract excerpt

ABSTRACT Bacterial pathogens use protein secretion systems to transport virulence factors and regulate gene expression. Among pathogenic mycobacteria, including Mycobacterium tuberculosis and Mycobacterium marinum , the ESAT-6 system 1 (ESX-1) secretion is crucial for host interaction. Secretion of protein substrates by the ESX-1 secretion system disrupts phagosomes, allowing mycobacteria cytoplasmic access...

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PMID: 38445877
DOI: 10.1128/mbio.03357-23

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The antagonistic transcription factors, EspM and EspN, regulate the ESX-1 secretion system in M. marinumPMID 38445877Read ↗

The antagonistic transcription factors, EspM and EspN, regulate the ESX-1 secretion system in <i>M. marinum</i>Semantic proximity Read ↗

The EspN transcription factor is an infection-dependent regulator of the ESX-1 system in <i>M. marinum</i>Semantic proximity Read ↗

EspM Is a Conserved Transcription Factor That Regulates Gene Expression in Response to the ESX-1 SystemSemantic proximity Read ↗

Conserved ESX-1 Substrates EspE and EspF Are Virulence Factors That Regulate Gene ExpressionSemantic proximity Read ↗

The regulatory functions of ESX-1 substrates, EspE and EspF, are separable from secretionSemantic proximity Read ↗

EspH is a hypervirulence factor for Mycobacterium marinum and essential for the secretion of the ESX-1 substrates EspE and EspFSemantic proximity Read ↗

Integrated transcriptomic and proteomic analysis of pathogenic mycobacteria and their esx-1 mutants reveal secretion-dependent regulation of ESX-1 substrates and WhiB6 as a transcriptional regulatorSemantic proximity Read ↗

WhiB6 is required for the secretion-dependent regulation of ESX-1 substrates in pathogenic mycobacteriaSemantic proximity Read ↗

Esx Paralogs Are Functionally Equivalent to ESX-1 Proteins but Are Dispensable for Virulence in Mycobacterium marinumSemantic proximity Read ↗

Functional Analysis of EspM, an ESX-1-Associated Transcription Factor in Mycobacterium marinumSemantic proximity Read ↗

WhiB6 regulation of ESX-1 gene expression is controlled by a negative feedback loop in Mycobacterium marinumSemantic proximity Read ↗

A mycobacterium ESX-1-secreted virulence factor with unique requirements for export.Semantic proximity Read ↗

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