Article

The loss of the PDIM/PGL virulence lipids causes differential secretion of ESX-1 substrates in <i>Mycobacterium marinum</i>

2024-01-10

Abstract excerpt

The mycobacterial cell envelope is a major virulence determinant in pathogenic mycobacteria. Specific outer lipids play roles in pathogenesis, modulating the immune system and promoting the secretion of virulence factors. ESX-1 (ESAT-6 system-1) is a conserved protein secretion system required for mycobacterial pathogenesis (1, 2). Previous studies revealed that mycobacterial strains lacking the outer lipid PDIM h...

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Literature Corpus work: 43015b0b-1b05-5d9f-899a-8a56c7453018
DOI: 10.1101/2024.01.09.574891

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