Article

The regulatory functions of ESX-1 substrates, EspE and EspF, are separable from secretion

2024-07-07

Abstract excerpt

Pathogenic mycobacteria are a significant global health burden. The ESX-1 secretion system is essential for mycobacterial pathogenesis. The secretion of ESX-1 substrates is required for phagosomal lysis, which allows the bacteria to enter the macrophage cytoplasm, induce a Type I IFN response, and spread to new host cells. EspE and EspF are dual- functioning ESX-1 substrates. Inside the mycobacterial cell, they re...

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Literature Corpus work: 3f7b5e6e-1412-50d4-ba9b-adc3d599e429
DOI: 10.1101/2024.07.05.602283

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