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The ESX-1 Substrate PPE68 Has a Key Function in ESX-1-Mediated Secretion in Mycobacterium marinum

21 Nov 2022

Abstract excerpt

Pathogenic mycobacteria, such Mycobacterium tuberculosis and Mycobacterium marinum, use a type VII secretion system (T7SS) subtype, called ESX-1, to mediate intracellular survival via phagosomal rupture and subsequent translocation of the mycobacterium to the host cytosol. Identifying the ESX-1 substrate that is responsible for this process is problematic because of the intricate network of codependent secretion...

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Antibiotic Resistance in Bacteria
Mycobacterium research and diagnosis
Tuberculosis Research and Epidemiology

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36409073
DOI: 10.1128/mbio.02819-22

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Click a neighbor to travelStep 1 · 12 closest

The ESX-1 Substrate PPE68 Has a Key Function in ESX-1-Mediated Secretion in Mycobacterium marinumPMID 36409073Read ↗

WhiB6 is required for the secretion-dependent regulation of ESX-1 substrates in pathogenic mycobacteriaSemantic proximity Read ↗

Modification of a PE/PPE substrate pair reroutes an Esx substrate pair from the mycobacterial ESX-1 type VII secretion system to the ESX-5 systemSemantic proximity Read ↗

A New ESX-1 Substrate in Mycobacterium marinum That Is Required for Hemolysis but Not Host Cell LysisSemantic proximity Read ↗

The regulatory functions of ESX-1 substrates, EspE and EspF, are separable from secretionSemantic proximity Read ↗

Proteo-genetic analysis reveals clear hierarchy of ESX-1 secretion in Mycobacterium marinumSemantic proximity Read ↗

Integrated transcriptomic and proteomic analysis of pathogenic mycobacteria and their esx-1 mutants reveal secretion-dependent regulation of ESX-1 substrates and WhiB6 as a transcriptional regulatorSemantic proximity Read ↗

ESX secretion system: The gatekeepers of mycobacterial survivability and pathogenesisSemantic proximity Read ↗

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A mycobacterium ESX-1-secreted virulence factor with unique requirements for export.Semantic proximity Read ↗

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