Article

Effects of psoriasis and psoralen exposure on the somatic mutation landscape of the skin

2022-07-09

Abstract excerpt

Somatic mutations are hypothesised to play a role in many non-neoplastic diseases. These diseases may also shape the somatic mutation landscape of affected tissues after onset. We performed whole-exome sequencing of 1182 microbiopsies dissected from lesional and non-lesional epidermis from 111 patients with psoriasis, a chronic inflammatory disease of the skin, to search for evidence that somatic mutations in kera...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d5441836-0c52-51b7-b0a5-bc9039a4e35a
DOI: 10.1101/2022.07.04.22277086

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Effects of psoriasis and psoralen exposure on the somatic mutation landscape of the skinDOI 10.1101/2022.07.04.22277086Read

Effects of psoriasis and psoralen exposure on the somatic mutation landscape of the skin.Semantic proximity Read

Mutational Landscape of Normal Human Skin: Clues to Understanding Early-Stage Carcinogenesis in Keratinocyte Neoplasia.Semantic proximity Read

Selection of Oncogenic Mutant Clones in Normal Human Skin Varies with Body Site.Semantic proximity Read

Mutation burden of narrowband ultraviolet B phototherapy (NB-UVB) in human skin: relevance to NB-UVB lifetime exposures and skin cancer surveillance.Semantic proximity Read

The landscape of driver mutations in cutaneous squamous cell carcinomaSemantic proximity Read

The landscape of driver mutations in cutaneous squamous cell carcinomaSemantic proximity Read

Transposon mutagenesis identifies cooperating genetic drivers during keratinocyte transformation and cutaneous squamous cell carcinoma progressionSemantic proximity Read

The Impact of Environmental and Endogenous Damage on Somatic Mutation Load in Human Skin Fibroblasts.Semantic proximity Read

Cell of origin and mutation pattern define three clinically distinct classes of sebaceous carcinoma.Semantic proximity Read

Further assessment of exome-wide UVR footprints in melanoma and their possible relevance.Semantic proximity Read

Whole exome-sequencing of vitiligo lesions indicate lower burden of somatic variations: implications in risk for non-melanoma skin cancersSemantic proximity Read

The effect of age on the acquisition and selection of cancer driver mutations in sun-exposed normal skin.Semantic proximity Read