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Block of both TGF-β and IL-2 signaling impedes Neurophilin-1+ regulatory T cell and follicular regulatory T cell development.

Cell death & disease - 27 Oct 2016

Li Liang, Yang Shu-Han, Yao Yuan, Xie Yu-Qing, Yang Yan-Qing, Wang Yin-Hu, Yin Xue-Ying, Ma Hong-Di, Gershwin MEric, Lian Zhe-Xiong

Abstract excerpt

Understanding the mechanisms that lead to autoimmunity is critical for defining potential therapeutic pathways. In this regard there have been considerable efforts in investigating the interacting roles of TGF-β and IL-2 on the function regulatory T cells. We have taken advantage of dnTGF-βRII Il2ra-/- (abbreviated as Il2ra-/-Tg) mouse model, which allows a direct mechanistic approach to define the relative roles...

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PMID: 27787514
DOI: 10.1038/cddis.2016.348
PMCID: PMC5134002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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