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Depletion of regulatory T cells leads to an exacerbation of delayed-type hypersensitivity arthritis in C57BL/6 mice that can be counteracted by IL-17 blockade.

Disease models & mechanisms - 1 Apr 2016

Atkinson Sara Marie, Hoffmann Ute, Hamann Alf, Bach Emil, Danneskiold-Samsøe Niels Banhos, Kristiansen Karsten, Serikawa Kyle, Fox Brian, Kruse Kim, Haase Claus, Skov Søren, Nansen Anneline

Abstract excerpt

Rodent models of arthritis have been extensively used in the elucidation of rheumatoid arthritis (RA) pathogenesis and are instrumental in the development of therapeutic strategies. Here we utilise delayed-type hypersensitivity arthritis (DTHA), a model in C57BL/6 mice affecting one paw with synchronised onset, 100% penetrance and low variation. We investigate the role of regulatory T cells (Tregs) in DTHA...

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Identifiers

PMID: 26822477
DOI: 10.1242/dmm.022905
PMCID: PMC4852503

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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