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TGF-β-induced Tregs release extracellular vesicles that modulate CD4+ T-cell proliferation and phenotype in a Nrp1-dependent manner.

ImmunoHorizons - 11 Apr 2026

Moya-Guzmán María José, González-Mienert Eduardo, Pinto Camila, Pino-Lagos Karina

Abstract excerpt

Neuropilin-1 (Nrp1) is one of the receptors for TGF-β and is associated with the suppressive function of T regulatory cells (Tregs). Based on previous findings on natural Tregs, this work investigated the role of Nrp1 on induced Tregs (iTregs) and their small extracellular vesicles (sEVs) by using a conditional knockout for Nrp1 on FoxP3+ cells. sEVs derived from iTregs were obtained by ultracentrifugation,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41968727
DOI: 10.1093/immhor/vlag019
PMCID: PMC13071156

Genes

CD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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