Article
Microbiota-induced IL-1β, but not IL-6, is critical for the development of steady-state TH17 cells in the intestine
30 Jan 2012
Abstract excerpt
T(H)17 cells are a lineage of CD4(+) T cells that are critical for host defense and autoimmunity by expressing the cytokines IL-17A, IL-17F, and IL-22. A feature of T(H)17 cells at steady state is their ubiquitous presence in the lamina propria of the small intestine. The induction of these steady-state intestinal T(H)17 (sT(H)17) cells is dependent on the presence of the microbiota. However, the signaling...
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