Article
Homeostatic IL-13 in healthy skin directs dendritic cell differentiation to promote TH2 and inhibit TH17 cell polarization.
Nature immunology - 1 Dec 2021
Mayer Johannes U, Hilligan Kerry L, Chandler Jodie S, Eccles David A, Old Samuel I, Domingues Rita G, Yang Jianping, Webb Greta R, Munoz-Erazo Luis, Hyde Evelyn J, Wakelin Kirsty A, Tang Shiau-Choot, Chappell Sally C, von Daake Sventja, Brombacher Frank, Mackay Charles R, Sher Alan, Tussiwand Roxane, Connor Lisa M, Gallego-Ortega David, Jankovic Dragana, Le Gros Graham, Hepworth Matthew R, Lamiable Olivier, Ronchese Franca
Abstract excerpt
The signals driving the adaptation of type 2 dendritic cells (DC2s) to diverse peripheral environments remain mostly undefined. We show that differentiation of CD11blo migratory DC2s-a DC2 population unique to the dermis-required IL-13 signaling dependent on the transcription factors STAT6 and KLF4, whereas DC2s in lung and small intestine were STAT6-independent. Similarly, human DC2s in skin expressed an IL-4...
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