Intestinal lamina propria dendritic cells maintain T cell homeostasis but do not affect commensalism.

Abstract excerpt

Dendritic cells (DCs) in the intestinal lamina propria (LP) are composed of two CD103(+) subsets that differ in CD11b expression. We report here that Langerin is expressed by human LP DCs and that transgenic human langerin drives expression in CD103(+)CD11b(+) LP DCs in mice. This subset was ablated in huLangerin-DTA mice, resulting in reduced LP Th17 cells without affecting Th1 or T reg cells. Notably, cognate...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to CD11b Antigen
• Share to Diphtheria Toxin