Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DC-derived IL-18 drives Treg differentiation, murine Helicobacter pylori-specific immune tolerance, and asthma protection.

The Journal of clinical investigation - 1 Mar 2012

Oertli Mathias, Sundquist Malin, Hitzler Iris, Engler Daniela B, Arnold Isabelle C, Reuter Sebastian, Maxeiner Joachim, Hansson Malin, Taube Christian, Quiding-Järbrink Marianne, Müller Anne

Abstract excerpt

Persistent colonization with the gastric bacterial pathogen Helicobacter pylori causes gastritis and predisposes infected individuals to gastric cancer. Conversely, it is also linked to protection from allergic, chronic inflammatory, and autoimmune diseases. We demonstrate here that H. pylori inhibits LPS-induced maturation of DCs and reprograms DCs toward a tolerance-promoting phenotype. Our results showed that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Coculture Techniques
Share to Gastric Mucosa

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Helicobacter Infections

Share to Helicobacter pylori

Share to Immune Tolerance

Share to Interleukin-18

Share to Interleukin-2 Receptor alpha Subunit

Share to T-Lymphocytes, Regulatory

Source

Open in PubMed Open full text

Identifiers

PMID: 22307326
DOI: 10.1172/JCI61029
PMCID: PMC3287234

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DC-derived IL-18 drives Treg differentiation, murine Helicobacter pylori-specific immune tolerance, and asthma protection.PMID 22307326Read ↗

Helicobacter pylori γ-glutamyl transpeptidase and vacuolating cytotoxin promote gastric persistence and immune toleranceSemantic proximity Read ↗

Dendritic cell function in the host response toHelicobacter pyloriinfection of the gastric mucosaSemantic proximity Read ↗

Inflammatory Th1 and Th17 in the Intestine Are Each Driven by Functionally Specialized Dendritic Cells with Distinct Requirements for MyD88.Semantic proximity Read ↗

<i>Helicobacter pylori</i> Cytotoxin-Associated Gene A Impairs Human Dendritic Cell Maturation and Function through IL-10–Mediated Activation of STAT3Semantic proximity Read ↗

Helicobacter urease–induced activation of the TLR2/NLRP3/IL-18 axis protects against asthmaSemantic proximity Read ↗

Therapeutic potential of tolerogenic dendritic cells in IBD: from animal models to clinical application.Semantic proximity Read ↗

Inflammation, Immunity, and Vaccines for HelicobacterSemantic proximity Read ↗

Intestinal Antigen-Presenting Cells: Key Regulators of Immune Homeostasis and Inflammation.Semantic proximity Read ↗

Th17-cell plasticity in Helicobacter hepaticus–induced intestinal inflammationSemantic proximity Read ↗

NLRP3 Controls the Development of Gastrointestinal CD11b+ Dendritic Cells in the Steady State and during Chronic Bacterial InfectionSemantic proximity Read ↗

A novel esophageal tolerogenic dendritic cell subsetSemantic proximity Read ↗

Direct contact with natural killer cells reprograms monocyte-derived dendritic cells into a tolerogenic phenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.