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Article

Structured observations reveal slow HIV-1 CTL escape.

PLoS genetics - 1 Feb 2015

Roberts Hannah E, Hurst Jacob, Robinson Nicola, Brown Helen, Flanagan Peter, Vass Laura, Fidler Sarah, Weber Jonathan, Babiker Abdel, Phillips Rodney E, McLean Angela R, Frater John

Abstract excerpt

The existence of viral variants that escape from the selection pressures imposed by cytotoxic T-lymphocytes (CTLs) in HIV-1 infection is well documented, but it is unclear when they arise, with reported measures of the time to escape in individuals ranging from days to years. A study of participants enrolled in the SPARTAC (Short Pulse Anti-Retroviral Therapy at HIV Seroconversion) clinical trial allowed direct...

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Share to pol Gene Products, Human Immunodeficiency Virus
Share to T-Lymphocytes, Cytotoxic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD8-Positive T-Lymphocytes

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Share to Gene Products, gag

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Share to nef Gene Products, Human Immunodeficiency Virus

Source

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Identifiers

PMID: 25642847
DOI: 10.1371/journal.pgen.1004914
PMCID: PMC4333731

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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