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Article

HLA-driven convergence of HIV-1 viral subtypes B and F toward the adaptation to immune responses in human populations.

PloS one - 1 Jan 2008

Dilernia Dario Alberto, Jones Leandro, Rodriguez Sabrina, Turk Gabriela, Rubio Andrea E, Pampuro Sandra, Gomez-Carrillo Manuel, Bautista Christian T, Bautista Christian, Deluchi Gabriel, Benetucci Jorge, Lasala María Beatriz, Lourtau Leonardo, Losso Marcelo Horacio, Perez Héctor, Cahn Pedro, Salomón Horacio

Abstract excerpt

BACKGROUND: Cytotoxic T-Lymphocyte (CTL) response drives the evolution of HIV-1 at a host-level by selecting HLA-restricted escape mutations. Dissecting the dynamics of these escape mutations at a population-level would help to understand how HLA-mediated selection drives the evolution of HIV-1. METHODOLOGY/PRINCIPAL FINDINGS: We undertook a study of the dynamics of HIV-1 CTL-escape mutations by analyzing through...

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Share to Antigens, Viral
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18941505
DOI: 10.1371/journal.pone.0003429
PMCID: PMC2565011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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