Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Increasingly successful highly active antiretroviral therapy delays the emergence of new HLA class I-associated escape mutations in HIV-1.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 1 Jun 2012

Knapp David J H F, Brumme Zabrina L, Huang Sheng Yuan, Wynhoven Brian, Dong Winnie W Y, Mo Theresa, Harrigan P Richard, Brumme Chanson J

Abstract excerpt

BACKGROUND: HLA class I-restricted cytotoxic T lymphocytes and highly active antiretroviral therapy (HAART) exert strong selective pressures on human immunodeficiency virus type 1 (HIV-1), leading to escape mutations compromising virologic control. Immune responses continue to shape HIV-1 evolution after HAART initiation, but the extent and rate at which this occurs remain incompletely quantified. Here, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antiretroviral Therapy, Highly Active
Share to British Columbia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epitopes, T-Lymphocyte

Share to Histocompatibility Antigens Class I

Share to Immune Evasion

Share to pol Gene Products, Human Immunodeficiency Virus

Share to T-Lymphocytes, Cytotoxic

Share to Viral Load

Source

Identifiers

PMID: 22460975
DOI: 10.1093/cid/cis253

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increasingly successful highly active antiretroviral therapy delays the emergence of new HLA class I-associated escape mutations in HIV-1.PMID 22460975Read ↗

Marked epitope- and allele-specific differences in rates of mutation in human immunodeficiency type 1 (HIV-1) Gag, Pol, and Nef cytotoxic T-lymphocyte epitopes in acute/early HIV-1 infection.Semantic proximity Read ↗

HLA-associated immune escape pathways in HIV-1 subtype B Gag, Pol and Nef proteins.Semantic proximity Read ↗

HLA-driven convergence of HIV-1 viral subtypes B and F toward the adaptation to immune responses in human populations.Semantic proximity Read ↗

Evidence of differential HLA class I-mediated viral evolution in functional and accessory/regulatory genes of HIV-1.Semantic proximity Read ↗

Early evolution of human leucocyte antigen-associated escape mutations in variable Gag proteins predicts CD4+ decline in HIV-1 subtype C-infected women.Semantic proximity Read ↗

HLA-Associated Clinical Progression Correlates with Epitope Reversion Rates in Early Human Immunodeficiency Virus InfectionSemantic proximity Read ↗

HLA Class-II Associated HIV Polymorphisms Predict Escape from CD4+ T Cell Responses.Semantic proximity Read ↗

HIV evolution in response to HLA-restricted CTL selection pressures: a population-based perspective.Semantic proximity Read ↗

Correlates of protective cellular immunity revealed by analysis of population-level immune escape pathways in HIV-1.Semantic proximity Read ↗

Population-Level Immune-Mediated Adaptation in HIV-1 Polymerase during the North American Epidemic.Semantic proximity Read ↗

HIV-1 adaptation to HLA: a window into virus-host immune interactions.Semantic proximity Read ↗

Widespread impact of HLA restriction on immune control and escape pathways of HIV-1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.