Article
CTL escape and increased viremia irrespective of HIV-specific CD4+ T-helper responses in two HIV-infected individuals.
Virology - 5 Feb 2006
Geels Mark J, Jansen Christine A, Baan Elly, De Cuyper Iris M, van Schijndel Gijs J M, Schuitemaker Hanneke, Goudsmit Jaap, Pollakis Georgios, Miedema Frank, Paxton William A, van Baarle Debbie
Abstract excerpt
We investigated whether development of mutations leads to loss of CD8 T-cell recognition in HIV-1 infection and is possibly linked to alterations in HIV-1-specific CD4(+) T-cell responses in 2 HIV-infected individuals. In patient, H434 full genome sequencing of HIV-1 biological clones at early and late time points during disease progression showed development of fixed mutations in 16 predicted HIV-specific CTL...
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