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Article

Functional avidity and IL-2/perforin production is linked to the emergence of mutations within HLA-B*5701-restricted epitopes and HIV-1 disease progression.

Journal of immunology (Baltimore, Md. : 1950) - 15 May 2014

Buggert Marcus, Norström Melissa M, Salemi Marco, Hecht Frederick M, Karlsson Annika C

Abstract excerpt

Viral escape from HIV-1-specific CD8(+) T cells has been demonstrated in numerous studies previously. However, the qualitative features driving the emergence of mutations within epitopes are still unclear. In this study, we aimed to distinguish whether specific functional characteristics of HLA-B*5701-restricted CD8(+) T cells influence the emergence of mutations in high-risk progressors (HRPs) versus low-risk...

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Source

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Identifiers

PMID: 24740510
DOI: 10.4049/jimmunol.1302253
PMCID: PMC4046013

Genes

MIP
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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