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Article

Hypomethylation of CYP11B2 in Aldosterone-Producing Adenoma.

Hypertension (Dallas, Tex. : 1979) - 1 Dec 2016

Yoshii Yoko, Oki Kenji, Gomez-Sanchez Celso E, Ohno Haruya, Itcho Kiyotaka, Kobuke Kazuhiro, Yoneda Masayasu

Abstract excerpt

The purpose of this study was to evaluate the DNA methylation levels of steroidogenic enzyme genes in aldosterone-producing adenoma (APA) and the effects of gene mutations in APA on the DNA methylation levels. DNA methylation array analysis was conducted using nonfunctioning adrenocortical adenoma (n=12) and APA (n=35) samples, including some with a KCNJ5 mutation (n=21), an ATP1A1 mutation (n=5), and without the...

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Share to Adrenocortical Adenoma
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to G Protein-Coupled Inwardly-Rectifying Potassium Channels

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Share to Real-Time Polymerase Chain Reaction

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Share to Sodium-Potassium-Exchanging ATPase

Share to Steroid 11-beta-Hydroxylase

Source

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Identifiers

PMID: 27754862
DOI: 10.1161/HYPERTENSIONAHA.116.08313
PMCID: PMC5159261

Genes

KCNJ5

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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