Article
Effect of KCNJ5 mutations on gene expression in aldosterone-producing adenomas and adrenocortical cells.
The Journal of clinical endocrinology and metabolism - 1 Aug 2012
Monticone Silvia, Hattangady Namita G, Nishimoto Koshiro, Mantero Franco, Rubin Beatrice, Cicala Maria Verena, Pezzani Raffaele, Auchus Richard J, Ghayee Hans K, Shibata Hirotaka, Kurihara Isao, Williams Tracy A, Giri Judith G, Bollag Roni J, Edwards Michael A, Isales Carlos M, Rainey William E
Abstract excerpt
CONTEXT: Primary aldosteronism is a heterogeneous disease that includes both sporadic and familial forms. A point mutation in the KCNJ5 gene is responsible for familial hyperaldosteronism type III. Somatic mutations in KCNJ5 also occur in sporadic aldosterone producing adenomas (APA). OBJECTIVE: The objective of the study was to define the effect of the KCNJ5 mutations on gene expression and aldosterone...
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