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Article

Cortisol overproduction results from DNA methylation of CYP11B1 in hypercortisolemia.

Scientific reports - 11 Sept 2017

Kometani Mitsuhiro, Yoneda Takashi, Demura Masashi, Koide Hiroshi, Nishimoto Koshiro, Mukai Kuniaki, Gomez-Sanchez Celso E, Akagi Tadayuki, Yokota Takashi, Horike Shin-Ichi, Karashima Shigehiro, Miyamori Isamu, Yamagishi Masakazu, Takeda Yoshiyu

Abstract excerpt

Adrenocortical hormone excess, due to primary aldosteronism (PA) or hypercortisolemia, causes hypertension and cardiovascular complications. In PA, hypomethylation of aldosterone synthase (CYP11B2) is associated with aldosterone overproduction. However, in hypercortisolemia, the role of DNA methylation of 11β-hydroxylase (CYP11B1), which catalyzes cortisol biosynthesis and is highly homologous to CYP11B2, is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28894201
DOI: 10.1038/s41598-017-11435-2
PMCID: PMC5594008

Genes

GNAS
PRKACA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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