Article
Characteristics of Japanese aldosterone-producing adenomas with KCNJ5 mutations.
Endocrine journal - 30 Jan 2017
Okamura Takashi, Nakajima Yasuyo, Katano-Toki Akiko, Horiguchi Kazuhiko, Matsumoto Shunichi, Yoshino Satoshi, Yamada Eijiro, Tomaru Takuya, Ishii Sumiyasu, Saito Tsugumichi, Ozawa Atsushi, Shibusawa Nobuyuki, Satoh Tetsurou, Okada Shuichi, Nagaoka Rin, Takada Daisuke, Horiguchi Jun, Oyama Tetsunari, Yamada Masanobu
Abstract excerpt
Somatic mutations in KCNJ5 gene have been identified in patients with adrenal aldosterone-producing adenomas (APAs). We previously reported that Japanese patients with APAs had distinct characteristics from patients in Western countries; i.e. they had a high frequency of KCNJ5 mutations and exhibited a frequent association with cortisol co-secretion. Therefore, APAs among Japanese patients may have different...
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