Article
Hypomethylation associated vitamin D receptor expression in ATP1A1 mutant aldosterone-producing adenoma.
Molecular and cellular endocrinology - 15 May 2022
Nanao Yuta, Oki Kenji, Kobuke Kazuhiro, Itcho Kiyotaka, Baba Ryuta, Kodama Takaya, Otagaki Yu, Okada Akira, Yoshii Yoko, Nagano Gaku, Ohno Haruya, Arihiro Koji, Gomez-Sanchez Celso E, Hattori Noboru, Yoneda Masayasu
Abstract excerpt
DNA methylation alteration is tissue-specific and play a pivotal role in regulating gene transcription during cell proliferation and survival. We aimed to detect genes regulated by DNA methylation, and then investigated whether the gene influenced cell proliferation or survival in adrenal cells. DNA methylation and qPCR analyses were performed in nonfunctioning adrenocortical adenoma (NFA, n = 12) and...
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