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Article

Purkinje Cell Protein 4 Expression Is Associated With DNA Methylation Status in Aldosterone-Producing Adenoma.

The Journal of clinical endocrinology and metabolism - 1 Mar 2018

Kobuke Kazuhiro, Oki Kenji, Gomez-Sanchez Celso E, Ohno Haruya, Itcho Kiyotaka, Yoshii Yoko, Yoneda Masayasu, Hattori Noboru

Abstract excerpt

Context: Aldosterone production is stimulated by activation of calcium signaling in aldosterone-producing adenomas (APAs), and epigenetic factors such as DNA methylation may be associated with the expression of genes involved in aldosterone regulation. Objective: Our aim was to investigate the DNA methylation of genes related to calcium signaling cascades in APAs and the association of mutations in genes linked...

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Topics

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Share to Adrenal Cortex Neoplasms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Calcium Signaling

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Share to DNA, Neoplasm

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Source

Identifiers

PMID: 29294065
DOI: 10.1210/jc.2017-01996

Genes

PCP4
KCNJ5

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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