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Article

α-Actinin-4 Is Essential for Maintaining the Spreading, Motility and Contractility of Fibroblasts

11 Nov 2010

Abstract excerpt

BACKGROUND: α-Actinins cross-link actin filaments, with this cross-linking activity regulating the formation of focal adhesions, intracellular tension, and cell migration. Most non-muscle cells such as fibroblasts express two isoforms, α-actinin-1 (ACTN1) and α-actinin-4 (ACTN4). The high homology between these two isoforms would suggest redundancy of their function, but recent studies have suggested different...

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PMID: 21085685
DOI: 10.1371/journal.pone.0013921

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