Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Focal Adhesion Assembly Induces Phenotypic Changes and Dedifferentiation in Chondrocytes.

Journal of cellular physiology - 1 Aug 2016

Shin Hyunjun, Lee Mi Nam, Choung Jin Seung, Kim Sanghee, Choi Byung Hyune, Noh Minsoo, Shin Jennifer H

Abstract excerpt

The expansion of autologous chondrocytes in vitro is used to generate sufficient populations for cell-based therapies. However, during monolayer culture, chondrocytes lose inherent characteristics and shift to fibroblast-like cells as passage number increase. Here, we investigated passage-dependent changes in cellular physiology, including cellular morphology, motility, and gene and protein expression, as well as...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aggrecans
Share to Cell Dedifferentiation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chondrogenesis

Share to Collagen Type II

Share to Focal Adhesion Kinase 1

Share to Focal Adhesions

Share to rho GTP-Binding Proteins

Share to SOX9 Transcription Factor

Source

Identifiers

PMID: 26661891
DOI: 10.1002/jcp.25290

Genes

SOX9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Focal Adhesion Assembly Induces Phenotypic Changes and Dedifferentiation in Chondrocytes.PMID 26661891Read ↗

Targeting F-actin stress fibers to suppress the dedifferentiated phenotype in chondrocytes.Semantic proximity Read ↗

Predicting how cells spread and migrateSemantic proximity Read ↗

Roles of focal adhesion proteins in skeleton and diseasesSemantic proximity Read ↗

Focal adhesion dynamics in cellular function and diseaseSemantic proximity Read ↗

MRTF-A signaling regulates the acquisition of the contractile phenotype in dedifferentiated chondrocytes.Semantic proximity Read ↗

Fibroblast Migration in FibrosisSemantic proximity Read ↗

Articular Chondrocyte Phenotype Regulation through the Cytoskeleton and the Signaling Processes That Originate from or Converge on the Cytoskeleton: Towards a Novel Understanding of the Intersection between Actin Dynamics and Chondrogenic Function.Semantic proximity Read ↗

Recent Research on Chondrocyte Dedifferentiation and Insights for Regenerative MedicineSemantic proximity Read ↗

Multiparametric analysis of focal adhesion formation by RNAi-mediated gene knockdownSemantic proximity Read ↗

P38 mitogen-activated protein kinase promotes dedifferentiation of primary articular chondrocytes in monolayer culture.Semantic proximity Read ↗

Required role of focal adhesion kinase (FAK) for integrin-stimulated cell migration.Semantic proximity Read ↗

Opposing FlnA and FlnB interactions regulate RhoA activation in guiding dynamic actin stress fiber formation and cell spreadingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.