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Activation of MRTF-A–dependent gene expression with a small molecule promotes myofibroblast differentiation and wound healing

30 Sept 2013

Abstract excerpt

Myocardin-related transcription factors (MRTFs) regulate cellular contractility and motility by associating with serum response factor (SRF) and activating genes involved in cytoskeletal dynamics. We reported previously that MRTF-A contributes to pathological cardiac remodeling by promoting differentiation of fibroblasts to myofibroblasts following myocardial infarction. Here, we show that forced expression of...

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PMID: 24082095
DOI: 10.1073/pnas.1316764110

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