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Article

The actin-MRTF-SRF gene regulatory axis and myofibroblast differentiation.

Journal of cardiovascular translational research - 1 Dec 2012

Small Eric M

Abstract excerpt

Cardiac fibroblasts are responsible for necrotic tissue replacement and scar formation after myocardial infarction (MI) and contribute to remodeling in response to pathological stimuli. This response to insult or injury is largely due to the phenotypic plasticity of fibroblasts. When fibroblasts encounter environmental disturbances, whether biomechanical or humoral, they often transform into smooth muscle-like,...

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Identifiers

PMID: 22898751
DOI: 10.1007/s12265-012-9397-0

Genes

SRF

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