Vascular smooth muscle cell phenotypic changes in patients with Marfan syndrome.

doi:10.1161/ATVBAHA.114.304412

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Article

Vascular smooth muscle cell phenotypic changes in patients with Marfan syndrome.

Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 2015

Crosas-Molist Eva, Meirelles Thayna, López-Luque Judit, Serra-Peinado Carla, Selva Javier, Caja Laia, Gorbenko Del Blanco Darya, Uriarte Juan José, Bertran Esther, Mendizábal Yolanda, Hernández Vanessa, García-Calero Carolina, Busnadiego Oscar, Condom Enric, Toral David, Castellà Manel, Forteza Alberto, Navajas Daniel, Sarri Elisabet, Rodríguez-Pascual Fernando, Dietz Harry C, Fabregat Isabel, Egea Gustavo

Abstract excerpt

OBJECTIVE: Marfan's syndrome is characterized by the formation of ascending aortic aneurysms resulting from altered assembly of extracellular matrix microfibrils and chronic tissue growth factor (TGF)-β signaling. TGF-β is a potent regulator of the vascular smooth muscle cell (VSMC) phenotype. We hypothesized that as a result of the chronic TGF-β signaling, VSMC would alter their basal differentiation phenotype,...

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Identifiers

PMID: 25593132
DOI: 10.1161/ATVBAHA.114.304412

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