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Article

Essential role of the Dishevelled DEP domain in a Wnt-dependent human-cell-based complementation assay.

Journal of cell science - 15 Oct 2016

Gammons Melissa V, Rutherford Trevor J, Steinhart Zachary, Angers Stephane, Bienz Mariann

Abstract excerpt

Dishevelled (DVL) assembles Wnt signalosomes through dynamic head-to-tail polymerisation by means of its DIX domain. It thus transduces Wnt signals to cytoplasmic effectors including β-catenin, to control cell fates during normal development, tissue homeostasis and also in cancer. To date, most functional studies of Dishevelled relied on its Wnt-independent signalling activity resulting from overexpression, which...

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Source

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Identifiers

PMID: 27744318
DOI: 10.1242/jcs.195685
PMCID: PMC5087658

Genes

DVL2
DVL1
DVL3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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