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Article

Regulation of Dishevelled DEP domain swapping by conserved phosphorylation sites.

Proceedings of the National Academy of Sciences of the United States of America - 29 Jun 2021

Beitia Gonzalo J, Rutherford Trevor J, Freund Stefan M V, Pelham Hugh R, Bienz Mariann, Gammons Melissa V

Abstract excerpt

Wnt signals bind to Frizzled receptors to trigger canonical and noncanonical signaling responses that control cell fates during animal development and tissue homeostasis. All Wnt signals are relayed by the hub protein Dishevelled. During canonical (β-catenin-dependent) signaling, Dishevelled assembles signalosomes via dynamic head-to-tail polymerization of its Dishevelled and Axin (DIX) domain, which are...

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Identifiers

PMID: 34155117
DOI: 10.1073/pnas.2103258118
PMCID: PMC8256032

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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