Article
Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl.
Molecular cell - 12 Mar 2010
Tauriello Daniele V F, Haegebarth Andrea, Kuper Ineke, Edelmann Mariola J, Henraat Marre, Canninga-van Dijk Marijke R, Kessler Benedikt M, Clevers Hans, Maurice Madelon M
Abstract excerpt
The mechanism by which Wnt receptors transduce signals to activate downstream beta-catenin-mediated target gene transcription remains incompletely understood but involves Frizzled (Fz) receptor-mediated plasma membrane recruitment and activation of the cytoplasmic effector Dishevelled (Dvl). Here, we identify the deubiquitinating enzyme CYLD, the familial cylindromatosis tumor suppressor gene, as a negative...
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