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Article

CYLD tidies up dishevelled signaling.

Molecular cell - 12 Mar 2010

Komander David

Abstract excerpt

An increasing number of cellular signaling pathways utilize protein ubiquitination for activation of signaling cascades. In this issue of Molecular Cell, Maurice and colleagues demonstrate that nondegradative Lys63-linked polyubiquitin chains modulate Dishevelled (Dvl) activity upstream in the Wnt/beta-catenin signaling pathway.

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20227361
DOI: 10.1016/j.molcel.2010.02.017

Genes

CYLD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

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CYLD tidies up dishevelled signaling.PMID 20227361Read ↗

Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl.Semantic proximity Read ↗

Regulation of Wnt Signaling through Ubiquitination and Deubiquitination in Cancers.Semantic proximity Read ↗

The E3 ubiquitin ligase ITCH negatively regulates canonical Wnt signaling by targeting dishevelled protein.Semantic proximity Read ↗

CYLD-Mediated Signaling and DiseasesSemantic proximity Read ↗

USP9X Deubiquitylates DVL2 to Regulate WNT Pathway SpecificationSemantic proximity Read ↗

Akt Phosphorylates Wnt Coactivator and Chromatin Effector Pygo2 at Serine 48 to Antagonize Its Ubiquitin/Proteasome-mediated Degradation.Semantic proximity Read ↗

Deubiquitinase UCHL5 stabilizes ELK3 to potentiate cancer stemness and tumor progression in pancreatic adenocarcinoma (PAAD)Semantic proximity Read ↗

The Wnt Signaling Antagonist Dapper1 Accelerates Dishevelled2 Degradation via Promoting Its Ubiquitination and Aggregate-induced Autophagy.Semantic proximity Read ↗

Loss of CYLD expression unleashes Wnt signaling in multiple myeloma and is associated with aggressive diseaseSemantic proximity Read ↗

Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in miceSemantic proximity Read ↗

The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis.Semantic proximity Read ↗

A targeted in vivo RNAi screen reveals deubiquitinases as new regulators of Notch signaling.Semantic proximity Read ↗

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