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Article

Disheveled regulates precoupling of heterotrimeric G proteins to Frizzled 6.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 May 2014

Kilander Michaela B C, Petersen Julian, Andressen Kjetil Wessel, Ganji Ranjani Sri, Levy Finn Olav, Schuster Jens, Dahl Niklas, Bryja Vitezslav, Schulte Gunnar

Abstract excerpt

Frizzleds (FZDs) are classified as G-protein-coupling receptors, but how signals are initiated and specified through heterotrimeric G proteins is unknown. FZD6 regulates convergent extension movements, and its C-terminal Arg511Cys mutation causes nail dysplasia in humans. We investigated the functional relationship between FZD6, Disheveled (DVL), and heterotrimeric G proteins. Live cell imaging combined with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24500924
DOI: 10.1096/fj.13-246363

Genes

FZD6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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