Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family.

The Journal of biological chemistry - 10 Dec 2004

Torban Elena, Wang Hui-Jun, Groulx Normand, Gros Philippe

Abstract excerpt

Mammalian Vangl1 and Vangl2 are highly conserved membrane proteins that have evolved from a single ancestral protein Strabismus/Van Gogh found in Drosophila. Mutations in the Vangl2 gene cause a neural tube defect (craniorachischisis) characteristic of the looptail (Lp) mouse. Studies in model organisms indicate that Vangl proteins play a key developmental role in establishing planar cell polarity (PCP) and in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Dishevelled Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA, Complementary

Share to Mice, Neurologic Mutants

Share to Neural Tube Defects

Share to Phosphoproteins

Share to Recombinant Fusion Proteins

Share to Two-Hybrid System Techniques

Source

Identifiers

PMID: 15456783
DOI: 10.1074/jbc.M408675200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family.PMID 15456783Read ↗

An expanding role of Vangl proteins in embryonic development.Semantic proximity Read ↗

Molecular and cellular mechanisms underlying neural tube defects in the loop-tail mutant mouse.Semantic proximity Read ↗

Tissue, cellular and sub-cellular localization of the Vangl2 protein during embryonic development: effect of the Lp mutation.Semantic proximity Read ↗

Identification and characterization of a novel chemically induced allele at the planar cell polarity gene Vangl2.Semantic proximity Read ↗

Genetic interaction between members of the Vangl family causes neural tube defects in mice.Semantic proximity Read ↗

The planar cell polarity gene Vangl2 is required for mammalian kidney-branching morphogenesis and glomerular maturationSemantic proximity Read ↗

Loss of membrane targeting of Vangl proteins causes neural tube defects.Semantic proximity Read ↗

Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development.Semantic proximity Read ↗

Dishevelled: in vivo roles of a multifunctional gene family during development.Semantic proximity Read ↗

Contribution of VANGL2 mutations to isolated neural tube defects.Semantic proximity Read ↗

Loop-tail phenotype in heterozygous mice and neural tube defects in homozygous mice result from a nonsense mutation in the Vangl2 gene.Semantic proximity Read ↗

A novel hypomorphic Looptail allele at the planar cell polarity Vangl2 gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.