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Article

Dishevelled promotes Wnt receptor degradation through recruitment of ZNRF3/RNF43 E3 ubiquitin ligases.

Molecular cell - 7 May 2015

Jiang Xiaomo, Charlat Olga, Zamponi Raffaella, Yang Yi, Cong Feng

Abstract excerpt

Tumor suppressors ZNRF3 and RNF43 inhibit Wnt signaling through promoting degradation of Wnt coreceptors Frizzled (FZD) and LRP6, and this activity is counteracted by stem cell growth factor R-spondin. The mechanism by which ZNRF3 and RNF43 recognize Wnt receptors remains unclear. Here we uncover an unexpected role of Dishevelled (DVL), a positive Wnt regulator, in promoting Wnt receptor degradation. DVL knockout...

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Share to Dishevelled Proteins
Share to Frizzled Receptors
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Low Density Lipoprotein Receptor-Related Protein-6

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Share to Wnt Signaling Pathway

Source

Identifiers

PMID: 25891077
DOI: 10.1016/j.molcel.2015.03.015

Genes

RNF43
ZNRF3
LRP6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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