Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structural analysis of the interaction between Dishevelled2 and clathrin AP-2 adaptor, a critical step in noncanonical Wnt signaling.

Structure (London, England : 1993) - 13 Oct 2010

Yu Anan, Xing Yi, Harrison Stephen C, Kirchhausen Tomas

Abstract excerpt

Wnt association with its receptor, Frizzled (Fz), and recruitment by the latter of an adaptor, Dishevelled (Dvl), initiates signaling through at least two distinct pathways ("canonical" and "noncanonical"). Endocytosis and compartmentalization help determine the signaling outcome. Our previous work has shown that Dvl2 links at least one Frizzled family member (Fz4) to clathrin-mediated endocytosis by interacting...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Protein Complex 2
Share to Clathrin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dishevelled Proteins

Share to Endocytosis

Share to Frizzled Receptors

Share to Phosphoproteins

Share to Receptors, G-Protein-Coupled

Share to Wnt Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 20947020
DOI: 10.1016/j.str.2010.07.010
PMCID: PMC2992793

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structural analysis of the interaction between Dishevelled2 and clathrin AP-2 adaptor, a critical step in noncanonical Wnt signaling.PMID 20947020Read ↗

Dishevelled promotes Wnt receptor degradation through recruitment of ZNRF3/RNF43 E3 ubiquitin ligases.Semantic proximity Read ↗

Identification of a PGXPP degron motif in dishevelled and structural basis for its binding to the E3 ligase KLHL12.Semantic proximity Read ↗

FRIZZLED 2 regulates limb development by mediating both β-catenin-dependent and independent Wnt signaling pathwaysSemantic proximity Read ↗

Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains.Semantic proximity Read ↗

Structure and function of the ROR2 cysteine-rich domain in vertebrate noncanonical WNT5A signalingSemantic proximity Read ↗

Dvl3 translocates IPMK to the cell membrane in response to Wnt.Semantic proximity Read ↗

Drosophila Tel2 is expressed as a translational fusion with EpsinR and is a regulator of wingless signaling.Semantic proximity Read ↗

Essential role of the Dishevelled DEP domain in a Wnt-dependent human-cell-based complementation assay.Semantic proximity Read ↗

High-affinity Dkk1 receptor Kremen1 is internalized by clathrin-mediated endocytosis.Semantic proximity Read ↗

Functional consequences of Wnt-induced dishevelled 2 phosphorylation in canonical and noncanonical Wnt signaling.Semantic proximity Read ↗

Disheveled regulates precoupling of heterotrimeric G proteins to Frizzled 6.Semantic proximity Read ↗

Structure-function dissection of the frizzled receptor in Drosophila melanogaster suggests different mechanisms of action in planar polarity and canonical Wnt signaling.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.